Allelic reprogramming of 3D chromatin architecture during early mammalian development

Zhenhai Du, Hui Zheng, Bo Huang, Rui Ma, Jingyi Wu, Xianglin Zhang, Jing He, Yunlong Xiang, Qiujun Wang, Yuanyuan Li, Jing Ma, Xu Zhang, Ke Zhang, Yang Wang, Michael Q. Zhang, Juntao Gao, Jesse R. Dixon, Xiaowo Wang, Jianyang Zeng and Wei Xie ()
Additional contact information
Zhenhai Du: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Hui Zheng: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Bo Huang: PKU-THU Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University
Rui Ma: Institute for Interdisciplinary Information Sciences, Tsinghua University
Jingyi Wu: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Xianglin Zhang: MOE Key Laboratory of Bioinformatics
Jing He: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Yunlong Xiang: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Qiujun Wang: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Yuanyuan Li: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Jing Ma: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Xu Zhang: MOE Key Laboratory of Bioinformatics
Ke Zhang: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University
Yang Wang: MOE Key Laboratory of Bioinformatics
Michael Q. Zhang: MOE Key Laboratory of Bioinformatics
Juntao Gao: MOE Key Laboratory of Bioinformatics
Jesse R. Dixon: The Salk Institute for Biological Studies
Xiaowo Wang: MOE Key Laboratory of Bioinformatics
Jianyang Zeng: Institute for Interdisciplinary Information Sciences, Tsinghua University
Wei Xie: Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University

Nature, 2017, vol. 547, issue 7662, 232-235

Abstract: A low-input Hi-C method is used to show that chromatin organization is markedly relaxed in pre-implantation mouse embryos after fertilization and that the subsequent maturation of 3D chromatin architecture is surprisingly slow.

Date: 2017
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DOI: 10.1038/nature23263

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