Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang and Feng Shao ()
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Yupeng Wang: College of Biological Sciences, China Agricultural University
Wenqing Gao: College of Biological Sciences, China Agricultural University
Xuyan Shi: College of Biological Sciences, China Agricultural University
Jingjin Ding: National Institute of Biological Sciences
Wang Liu: National Institute of Biological Sciences
Huabin He: National Institute of Biological Sciences
Kun Wang: National Institute of Biological Sciences
Feng Shao: National Institute of Biological Sciences

Nature, 2017, vol. 547, issue 7661, 99-103

Abstract: Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.

Date: 2017
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DOI: 10.1038/nature22393

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