Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil D. Dhruv, Shubhroz Gill, Ossia M. Eichhoff, Brinton Seashore-Ludlow, Samuel D. Kaffenberger, John K. Eaton, Kenichi Shimada, Andrew J. Aguirre, Srinivas R. Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G. Rees, Sixun Chen, Zarko V. Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, Elisabeth M. Roider, Dong Gao, James M. Cleary, Brian M. Wolpin, Jill P. Mesirov, Daniel A. Haber, Jeffrey A. Engelman, Jesse S. Boehm, Joanne D. Kotz, Cindy S. Hon, Yu Chen, William C. Hahn, Mitchell P. Levesque, John G. Doench, Michael E. Berens, Alykhan F. Shamji, Paul A. Clemons, Brent R. Stockwell and Stuart L. Schreiber ()
Additional contact information
Vasanthi S. Viswanathan: Broad Institute
Matthew J. Ryan: Broad Institute
Harshil D. Dhruv: The Translational Genomics Research Institute
Shubhroz Gill: Broad Institute
Ossia M. Eichhoff: University of Zurich
Brinton Seashore-Ludlow: Broad Institute
Samuel D. Kaffenberger: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
John K. Eaton: Broad Institute
Kenichi Shimada: Laboratory of Systems Pharmacology, Harvard Medical School
Andrew J. Aguirre: Broad Institute
Srinivas R. Viswanathan: Broad Institute
Shrikanta Chattopadhyay: Broad Institute
Pablo Tamayo: Broad Institute
Wan Seok Yang: St. John’s University
Matthew G. Rees: Broad Institute
Sixun Chen: Broad Institute
Zarko V. Boskovic: Broad Institute
Sarah Javaid: Massachusetts General Hospital Cancer Center
Cherrie Huang: Broad Institute
Xiaoyun Wu: Broad Institute
Yuen-Yi Tseng: Broad Institute
Elisabeth M. Roider: University of Zurich
Dong Gao: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
James M. Cleary: Dana Farber Cancer Institute
Brian M. Wolpin: Dana Farber Cancer Institute
Jill P. Mesirov: Broad Institute
Daniel A. Haber: Massachusetts General Hospital Cancer Center
Jeffrey A. Engelman: Oncology Disease Area, Novartis Institute for Biomedical Research
Jesse S. Boehm: Broad Institute
Joanne D. Kotz: Broad Institute
Cindy S. Hon: Broad Institute
Yu Chen: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
William C. Hahn: Broad Institute
Mitchell P. Levesque: University of Zurich
John G. Doench: Broad Institute
Michael E. Berens: The Translational Genomics Research Institute
Alykhan F. Shamji: Broad Institute
Paul A. Clemons: Broad Institute
Brent R. Stockwell: Columbia University
Stuart L. Schreiber: Broad Institute

Nature, 2017, vol. 547, issue 7664, 453-457

Abstract: Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

Date: 2017
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DOI: 10.1038/nature23007

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