Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

Collin Y. Ewald, Jess N. Landis, Jess Porter Abate, Coleen T. Murphy () and T. Keith Blackwell ()
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Collin Y. Ewald: Joslin Diabetes Center, One Joslin Place
Jess N. Landis: Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA
Jess Porter Abate: Joslin Diabetes Center, One Joslin Place
Coleen T. Murphy: Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA
T. Keith Blackwell: Joslin Diabetes Center, One Joslin Place

Nature, 2015, vol. 519, issue 7541, 97-101

Abstract: In Caenorhabditis elegans, reduced insulin/IGF-1 signalling can promote longevity through a program that is genetically distinct from the dauer developmental pathway, and requires SKN-1-dependent collagen remodelling that is a broadly essential feature of longevity assurance pathways.

Date: 2015
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DOI: 10.1038/nature14021

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