AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Matthew R. Gardner, Lisa M. Kattenhorn, Hema R. Kondur, Markus von Schaewen, Tatyana Dorfman, Jessica J. Chiang, Kevin G. Haworth, Julie M. Decker, Michael D. Alpert, Charles C. Bailey, Ernest S. Neale, Christoph H. Fellinger, Vinita R. Joshi, Sebastian P. Fuchs, Jose M. Martinez-Navio, Brian D. Quinlan, Annie Y. Yao, Hugo Mouquet, Jason Gorman, Baoshan Zhang, Pascal Poignard, Michel C. Nussenzweig, Dennis R. Burton, Peter D. Kwong, Michael Piatak, Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers, David T. Evans, Beatrice H. Hahn, Alexander Ploss, Paula M. Cannon, Michael S. Seaman and Michael Farzan ()
Additional contact information
Matthew R. Gardner: The Scripps Research Institute
Lisa M. Kattenhorn: Harvard Medical School, New England Primate Research Center
Hema R. Kondur: The Scripps Research Institute
Markus von Schaewen: Princeton University
Tatyana Dorfman: The Scripps Research Institute
Jessica J. Chiang: Harvard Medical School, New England Primate Research Center
Kevin G. Haworth: Keck School of Medicine of the University of Southern California
Julie M. Decker: Perelman School of Medicine, University of Pennsylvania
Michael D. Alpert: Harvard Medical School, New England Primate Research Center
Charles C. Bailey: The Scripps Research Institute
Ernest S. Neale: Harvard Medical School, New England Primate Research Center
Christoph H. Fellinger: The Scripps Research Institute
Vinita R. Joshi: The Scripps Research Institute
Sebastian P. Fuchs: University of Miami Miller School of Medicine
Jose M. Martinez-Navio: University of Miami Miller School of Medicine
Brian D. Quinlan: The Scripps Research Institute
Annie Y. Yao: Harvard Medical School, New England Primate Research Center
Hugo Mouquet: Laboratory of Molecular Immunology, The Rockefeller University
Jason Gorman: Vaccine Research Center, National Institutes of Health
Baoshan Zhang: Vaccine Research Center, National Institutes of Health
Pascal Poignard: IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University
Dennis R. Burton: IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
Peter D. Kwong: Vaccine Research Center, National Institutes of Health
Michael Piatak: AIDS and Cancer Virus Program, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Jeffrey D. Lifson: AIDS and Cancer Virus Program, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Guangping Gao: Gene Therapy Center, University of Massachusetts Medical School
Ronald C. Desrosiers: Harvard Medical School, New England Primate Research Center
David T. Evans: University of Wisconsin
Beatrice H. Hahn: Perelman School of Medicine, University of Pennsylvania
Alexander Ploss: Princeton University
Paula M. Cannon: Keck School of Medicine of the University of Southern California
Michael S. Seaman: Beth Israel Deaconess Medical Center
Michael Farzan: The Scripps Research Institute

Nature, 2015, vol. 519, issue 7541, 87-91

Abstract: The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neutralize 100% of a diverse panel of neutralization-resistant HIV-1 viruses, and when delivered to macaques using an adeno-associated virus vector, it can provide effective long-term protection from multiple challenges with simian/human immunodeficiency virus.

Date: 2015
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DOI: 10.1038/nature14264

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