Lineage correlations of single cell division time as a probe of cell-cycle dynamics

Oded Sandler, Sivan Pearl Mizrahi, Noga Weiss, Oded Agam (), Itamar Simon () and Nathalie Q. Balaban ()
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Oded Sandler: IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Sivan Pearl Mizrahi: IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Noga Weiss: Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel
Oded Agam: Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel
Itamar Simon: IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nathalie Q. Balaban: Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel

Nature, 2015, vol. 519, issue 7544, 468-471

Abstract: Precise measurement of cell-cycle duration in thousands of mammalian cells reveals correlations among cousin cells, but no such correlations between mother and daughter cells; recapitulating this finding using a deterministic model suggests that observed cellular heterogeneities in cell-cycle duration may be attributable to deterministic processes, and eventually be controlled.

Date: 2015
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DOI: 10.1038/nature14318

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