hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1

Yoichiro Sugimoto, Alessandra Vigilante, Elodie Darbo, Alexandra Zirra, Cristina Militti, Andrea D’Ambrogio, Nicholas M. Luscombe () and Jernej Ule ()
Additional contact information
Yoichiro Sugimoto: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK
Alessandra Vigilante: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Elodie Darbo: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Alexandra Zirra: UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Cristina Militti: UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Andrea D’Ambrogio: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK
Nicholas M. Luscombe: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Jernej Ule: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK

Nature, 2015, vol. 519, issue 7544, 491-494

Abstract: A method, termed hiCLIP, has been developed to determine the RNA duplexes bound by RNA-binding proteins, revealing an unforeseen prevalence of long-range duplexes in 3′ untranslated regions (UTRs), and a decreased incidence of SNPs in duplex-forming regions; the results also show that RNA structure is able to regulate gene expression.

Date: 2015
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DOI: 10.1038/nature14280

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