Initiation of translation in bacteria by a structured eukaryotic IRES RNA

Timothy M. Colussi, David A. Costantino, Jianyu Zhu, John Paul Donohue, Andrei A. Korostelev, Zane A. Jaafar, Terra-Dawn M. Plank, Harry F. Noller and Jeffrey S. Kieft ()
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Timothy M. Colussi: University of Colorado Denver School of Medicine
David A. Costantino: University of Colorado Denver School of Medicine
Jianyu Zhu: Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
John Paul Donohue: Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
Andrei A. Korostelev: Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
Zane A. Jaafar: University of Colorado Denver School of Medicine
Terra-Dawn M. Plank: University of Colorado Denver School of Medicine
Harry F. Noller: Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
Jeffrey S. Kieft: University of Colorado Denver School of Medicine

Nature, 2015, vol. 519, issue 7541, 110-113

Abstract: A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

Date: 2015
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DOI: 10.1038/nature14219

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