Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Jonathan R. Brestoff, Brian S. Kim, Steven A. Saenz, Rachel R. Stine, Laurel A. Monticelli, Gregory F. Sonnenberg, Joseph J. Thome, Donna L. Farber, Kabirullah Lutfy, Patrick Seale and David Artis ()
Additional contact information
Jonathan R. Brestoff: Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
Brian S. Kim: Perelman School of Medicine, University of Pennsylvania
Steven A. Saenz: Perelman School of Medicine, University of Pennsylvania
Rachel R. Stine: Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
Laurel A. Monticelli: Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
Gregory F. Sonnenberg: Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
Joseph J. Thome: Columbia Center for Translational Immunology, Columbia University Medical Center
Donna L. Farber: Columbia Center for Translational Immunology, Columbia University Medical Center
Kabirullah Lutfy: College of Pharmacy, Western University of Health Sciences
Patrick Seale: Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
David Artis: Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University

Nature, 2015, vol. 519, issue 7542, 242-246

Abstract: Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

Date: 2015
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DOI: 10.1038/nature14115

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