Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Duane A. Mitchell (), Kristen A. Batich, Michael D. Gunn, Min-Nung Huang, Luis Sanchez-Perez, Smita K. Nair, Kendra L. Congdon, Elizabeth A. Reap, Gary E. Archer, Annick Desjardins, Allan H. Friedman, Henry S. Friedman, James E. Herndon, April Coan, Roger E. McLendon, David A. Reardon, James J. Vredenburgh, Darell D. Bigner and John H. Sampson ()
Additional contact information
Duane A. Mitchell: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Kristen A. Batich: Duke University Medical Center
Michael D. Gunn: Duke University Medical Center
Min-Nung Huang: Duke University Medical Center
Luis Sanchez-Perez: Duke University Medical Center
Smita K. Nair: Duke University Medical Center
Kendra L. Congdon: Duke University Medical Center
Elizabeth A. Reap: Duke University Medical Center
Gary E. Archer: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Annick Desjardins: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Allan H. Friedman: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Henry S. Friedman: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
James E. Herndon: Duke University Medical Center
April Coan: Duke University Medical Center
Roger E. McLendon: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
David A. Reardon: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
James J. Vredenburgh: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Darell D. Bigner: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
John H. Sampson: Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA

Nature, 2015, vol. 519, issue 7543, 366-369

Abstract: A clinical trial in patients with glioblastoma shows increased immune and anti-tumour responses to dendritic cell vaccination after pre-conditioning the site of vaccination with tetanus toxoid (Td); similar results are also seen in mice in part due to the actions of the chemokine CCL3, and the findings may represent new ways to improve the efficacy of anti-cancer vaccines.

Date: 2015
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DOI: 10.1038/nature14320

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