Disarming Wnt

Roel Nusse ()
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Roel Nusse: Roel Nusse is at the Howard Hughes Medical Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5458, USA.

Nature, 2015, vol. 519, issue 7542, 163-164

Abstract: The secreted enzyme Notum has been found to inhibit the Wnt signalling pathway through removal of a lipid that is linked to the Wnt protein and that is required for activation of Wnt receptor proteins. See Article p.187

Date: 2015
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DOI: 10.1038/nature14208

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