Structural imprints in vivo decode RNA regulatory mechanisms

Robert C. Spitale, Ryan A. Flynn, Qiangfeng Cliff Zhang, Pete Crisalli, Byron Lee, Jong-Wha Jung, Hannes Y. Kuchelmeister, Pedro J. Batista, Eduardo A. Torre, Eric T. Kool () and Howard Y. Chang ()
Additional contact information
Robert C. Spitale: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Ryan A. Flynn: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Qiangfeng Cliff Zhang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Pete Crisalli: Stanford University
Byron Lee: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Jong-Wha Jung: Stanford University
Hannes Y. Kuchelmeister: Stanford University
Pedro J. Batista: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Eduardo A. Torre: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Eric T. Kool: Stanford University
Howard Y. Chang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine

Nature, 2015, vol. 519, issue 7544, 486-490

Abstract: The single-stranded nature of RNAs synthesized in the cell gives them great scope to form different structures, but current methods to measure RNA structure in vivo are limited; now, a new methodology allows researchers to examine all four nucleotides in mouse embryonic stem cells.

Date: 2015
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DOI: 10.1038/nature14263

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