In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernandez-Benitez, Jun Wu, Jie Zhu, Euiseok J. Kim, Fumiyuki Hatanaka, Mako Yamamoto, Toshikazu Araoka, Zhe Li, Masakazu Kurita, Tomoaki Hishida, Mo Li, Emi Aizawa, Shicheng Guo, Song Chen, April Goebl, Rupa Devi Soligalla, Jing Qu, Tingshuai Jiang, Xin Fu, Maryam Jafari, Concepcion Rodriguez Esteban, W. Travis Berggren, Jeronimo Lajara, Estrella Nuñez-Delicado, Pedro Guillen, Josep M. Campistol, Fumio Matsuzaki, Guang-Hui Liu, Pierre Magistretti, Kun Zhang, Edward M. Callaway, Kang Zhang and Juan Carlos Izpisua Belmonte ()
Additional contact information
Keiichiro Suzuki: Gene Expression Laboratory, Salk Institute for Biological Studies
Yuji Tsunekawa: Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology
Reyna Hernandez-Benitez: Gene Expression Laboratory, Salk Institute for Biological Studies
Jun Wu: Gene Expression Laboratory, Salk Institute for Biological Studies
Jie Zhu: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
Euiseok J. Kim: Systems Neurobiology Laboratory, Salk Institute for Biological Studies
Fumiyuki Hatanaka: Gene Expression Laboratory, Salk Institute for Biological Studies
Mako Yamamoto: Gene Expression Laboratory, Salk Institute for Biological Studies
Toshikazu Araoka: Gene Expression Laboratory, Salk Institute for Biological Studies
Zhe Li: Bioengineering, University of California, San Diego
Masakazu Kurita: Gene Expression Laboratory, Salk Institute for Biological Studies
Tomoaki Hishida: Gene Expression Laboratory, Salk Institute for Biological Studies
Mo Li: Gene Expression Laboratory, Salk Institute for Biological Studies
Emi Aizawa: Gene Expression Laboratory, Salk Institute for Biological Studies
Shicheng Guo: Bioengineering, University of California, San Diego
April Goebl: Gene Expression Laboratory, Salk Institute for Biological Studies
Rupa Devi Soligalla: Gene Expression Laboratory, Salk Institute for Biological Studies
Jing Qu: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Tingshuai Jiang: Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego
Xin Fu: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
Maryam Jafari: Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego
Concepcion Rodriguez Esteban: Gene Expression Laboratory, Salk Institute for Biological Studies
W. Travis Berggren: Salk Institute for Biological Studies
Jeronimo Lajara: Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos
Estrella Nuñez-Delicado: Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos
Pedro Guillen: Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos
Josep M. Campistol: Hospital Clinic, University of Barcelona, IDIBAPS
Fumio Matsuzaki: Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology
Guang-Hui Liu: University of Chinese Academy of Sciences
Pierre Magistretti: 4700 King Abdullah University of Science and Technology (KAUST)
Kun Zhang: Bioengineering, University of California, San Diego
Edward M. Callaway: Systems Neurobiology Laboratory, Salk Institute for Biological Studies
Kang Zhang: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
Juan Carlos Izpisua Belmonte: Gene Expression Laboratory, Salk Institute for Biological Studies

Nature, 2016, vol. 540, issue 7631, 144-149

Abstract: A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.

Date: 2016
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Citations: View citations in EconPapers (22)

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DOI: 10.1038/nature20565

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