Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

Li Wang, Jiang-Yun Luo, Bochuan Li, Xiao Yu Tian, Li-Jing Chen, Yuhong Huang, Jian Liu, Dan Deng, Chi Wai Lau, Song Wan, Ding Ai, King-Lun Kingston Mak, Ka Kui Tong, Kin Ming Kwan, Nanping Wang, Jeng-Jiann Chiu, Yi Zhu () and Yu Huang ()
Additional contact information
Li Wang: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Jiang-Yun Luo: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Bochuan Li: Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
Xiao Yu Tian: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Li-Jing Chen: Institute of Cellular and System Medicine, National Health Research Institutes
Yuhong Huang: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Jian Liu: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Dan Deng: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Chi Wai Lau: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
Song Wan: Chinese University of Hong Kong
Ding Ai: Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
King-Lun Kingston Mak: School of Biomedical Sciences, Chinese University of Hong Kong
Ka Kui Tong: School of Life Sciences, Chinese University of Hong Kong
Kin Ming Kwan: School of Life Sciences, Chinese University of Hong Kong
Nanping Wang: Advanced Institute for Medical Sciences, Dalian Medical University
Jeng-Jiann Chiu: Institute of Cellular and System Medicine, National Health Research Institutes
Yi Zhu: Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
Yu Huang: Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong

Nature, 2016, vol. 540, issue 7634, 579-582

Abstract: YAP and TAZ, effectors of the Hippo pathway, sense mechanical forces generated by blood flow and play a role in atherosclerosis pathogenesis.

Date: 2016
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DOI: 10.1038/nature20602

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