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Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky and Todd K. Hyster ()
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Megan A. Emmanuel: Princeton University
Norman R. Greenberg: Princeton University
Daniel G. Oblinsky: Princeton University
Todd K. Hyster: Princeton University

Nature, 2016, vol. 540, issue 7633, 414-417

Abstract: hotoexcitation of a catalytic enzyme enzyme’s co-factor is shown to change the reactivity of the enzyme, enabling it to carry out a non-natural enantioselective dehalogenation of lactone molecules.

Date: 2016
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DOI: 10.1038/nature20569

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