Cause and consequence in aged-muscle decline

Susan Eliazer and Andrew S. Brack ()
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Susan Eliazer: Susan Eliazer and Andrew S. Brack are in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA.
Andrew S. Brack: Susan Eliazer and Andrew S. Brack are in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA.

Nature, 2016, vol. 540, issue 7633, 349-350

Abstract: Activation of aged muscle stem cells induces changes in DNA packaging that lead to expression of the gene Hoxa9. This reactivates embryonic signalling pathways, restricting the cells' ability to repair injured muscle. See Letter p.428

Date: 2016
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DOI: 10.1038/nature20485

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