Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

Erica N. Borducchi, Crystal Cabral, Kathryn E. Stephenson, Jinyan Liu, Peter Abbink, David Ng’ang’a, Joseph P. Nkolola, Amanda L. Brinkman, Lauren Peter, Benjamin C. Lee, Jessica Jimenez, David Jetton, Jade Mondesir, Shanell Mojta, Abishek Chandrashekar, Katherine Molloy, Galit Alter, Jeffrey M. Gerold, Alison L. Hill, Mark G. Lewis, Maria G. Pau, Hanneke Schuitemaker, Joseph Hesselgesser, Romas Geleziunas, Jerome H. Kim, Merlin L. Robb, Nelson L. Michael and Dan H. Barouch ()
Additional contact information
Erica N. Borducchi: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Crystal Cabral: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Kathryn E. Stephenson: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jinyan Liu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Peter Abbink: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
David Ng’ang’a: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Joseph P. Nkolola: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Amanda L. Brinkman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Lauren Peter: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Benjamin C. Lee: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jessica Jimenez: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
David Jetton: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jade Mondesir: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Shanell Mojta: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Abishek Chandrashekar: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Katherine Molloy: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Galit Alter: Ragon Institute of MGH, MIT, and Harvard
Jeffrey M. Gerold: Program for Evolutionary Dynamics, Harvard University
Alison L. Hill: Program for Evolutionary Dynamics, Harvard University
Mark G. Lewis: Bioqual
Maria G. Pau: Janssen Infectious Diseases and Vaccines
Hanneke Schuitemaker: Janssen Infectious Diseases and Vaccines
Joseph Hesselgesser: Gilead Sciences
Romas Geleziunas: Gilead Sciences
Jerome H. Kim: US Military HIV Research Program, Walter Reed Army Institute of Research
Merlin L. Robb: US Military HIV Research Program, Walter Reed Army Institute of Research
Nelson L. Michael: US Military HIV Research Program, Walter Reed Army Institute of Research
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2016, vol. 540, issue 7632, 284-287

Abstract: A combination of therapeutic vaccination with Ad26/MVA and stimulation of innate immune responses leads to improved virologic control and delayed rebound in SIV-infected macaques following discontinuation of antiretroviral therapy.

Date: 2016
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DOI: 10.1038/nature20583

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