Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Simon Schwörer, Friedrich Becker, Christian Feller, Ali H. Baig, Ute Köber, Henriette Henze, Johann M. Kraus, Beibei Xin, André Lechel, Daniel B. Lipka, Christy S. Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L. Medina, Hans A. Kestler, Francesco Neri, Julia von Maltzahn (), Stefan Tümpel () and K. Lenhard Rudolph ()
Additional contact information
Simon Schwörer: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Friedrich Becker: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Christian Feller: Institute of Molecular Systems Biology, ETH Zürich
Ali H. Baig: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Ute Köber: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Henriette Henze: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Johann M. Kraus: Institute of Medical Systems Biology, Ulm University
Beibei Xin: Molecular and Computational Biology Program, University of Southern California
André Lechel: Ulm University
Daniel B. Lipka: DKFZ
Christy S. Varghese: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Manuel Schmidt: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Remo Rohs: Molecular and Computational Biology Program, University of Southern California
Ruedi Aebersold: Institute of Molecular Systems Biology, ETH Zürich
Kay L. Medina: Mayo Clinic
Hans A. Kestler: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Francesco Neri: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Julia von Maltzahn: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
Stefan Tümpel: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)
K. Lenhard Rudolph: Leibniz-Institute on Aging – Fritz Lipmann Institute (FLI)

Nature, 2016, vol. 540, issue 7633, 428-432

Abstract: Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature20603 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:540:y:2016:i:7633:d:10.1038_nature20603

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature20603

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().