Inhibition of mTOR induces a paused pluripotent state

Aydan Bulut-Karslioglu, Steffen Biechele, Hu Jin, Trisha A. Macrae, Miroslav Hejna, Marina Gertsenstein, Jun S. Song and Miguel Ramalho-Santos ()
Additional contact information
Aydan Bulut-Karslioglu: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California
Steffen Biechele: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California
Hu Jin: Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
Trisha A. Macrae: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California
Miroslav Hejna: Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
Marina Gertsenstein: The Centre for Phenogenomics (TCP)
Jun S. Song: Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign
Miguel Ramalho-Santos: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences and Diabetes Center, University of California

Nature, 2016, vol. 540, issue 7631, 119-123

Abstract: Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature20578 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20578

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature20578

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().