RIPK1 inhibits ZBP1-driven necroptosis during development

Kim Newton (), Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Andreas Strasser, Victoria C. Pham, Jennie R. Lill, Merone Roose-Girma, Søren Warming, Margaret Solon, Hai Ngu, Joshua D. Webster and Vishva M. Dixit ()
Additional contact information
Kim Newton: Genentech
Katherine E. Wickliffe: Genentech
Allie Maltzman: Genentech
Debra L. Dugger: Genentech
Andreas Strasser: The Walter and Eliza Hall Institute of Medical Research
Victoria C. Pham: Genentech
Jennie R. Lill: Genentech
Merone Roose-Girma: Genentech
Søren Warming: Genentech
Margaret Solon: Genentech
Hai Ngu: Genentech
Joshua D. Webster: Genentech
Vishva M. Dixit: Genentech

Nature, 2016, vol. 540, issue 7631, 129-133

Abstract: In the absence of RIPK1, ZBP1 engages RIPK3 in a RHIM-dependent manner and acts as a critical activator of RIPK3/MLKL-dependent necroptosis.

Date: 2016
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DOI: 10.1038/nature20559

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