Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis

Alisa A. Mueller, Cindy T. van Velthoven, Kathryn D. Fukumoto, Tom H. Cheung and Thomas A. Rando ()
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Alisa A. Mueller: Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
Cindy T. van Velthoven: Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
Kathryn D. Fukumoto: Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
Tom H. Cheung: Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine
Thomas A. Rando: Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine

Nature, 2016, vol. 540, issue 7632, 276-279

Abstract: Changes in intronic polyadenylation of the Pdgfra in fibro/adipogenic progenitors lead to increased expression of a shorter variant with a truncated kinase domain, which modulates pro-fibrotic pathways to reduce tissue fibrosis in muscle.

Date: 2016
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DOI: 10.1038/nature20160

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