mRNA quality control is bypassed for immediate export of stress-responsive transcripts

Gesa Zander, Alexandra Hackmann, Lysann Bender, Daniel Becker, Thomas Lingner, Gabriela Salinas and Heike Krebber ()
Additional contact information
Gesa Zander: Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen
Alexandra Hackmann: Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen
Lysann Bender: Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen
Daniel Becker: Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen
Thomas Lingner: Transkriptomanalyselabor, Institut für Entwicklungsbiochemie, Georg-August Universität Göttingen
Gabriela Salinas: Transkriptomanalyselabor, Institut für Entwicklungsbiochemie, Georg-August Universität Göttingen
Heike Krebber: Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August Universität Göttingen

Nature, 2016, vol. 540, issue 7634, 593-596

Abstract: Heat shock drives the expression of transcripts that bypass mRNA quality control for direct export and translation, allowing cells to survive extreme situations at the cost of accuracy.

Date: 2016
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DOI: 10.1038/nature20572

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