Selective control of parasitic nematodes using bioactivated nematicides

Andrew R. Burns (), Rachel J. Baker, Megan Kitner, Jessica Knox, Brittany Cooke, Jonathan R. Volpatti, Aditya S. Vaidya, Emily Puumala, Bruna M. Palmeira, Elizabeth M. Redman, Jamie Snider, Sagar Marwah, Sai W. Chung, Margaret H. MacDonald, Jens Tiefenbach, Chun Hu, Qi Xiao, Constance A. M. Finney, Henry M. Krause, Sonya A. MacParland, Igor Stagljar, John S. Gilleard, Leah E. Cowen, Susan L. F. Meyer, Sean R. Cutler, James J. Dowling, Mark Lautens, Inga Zasada and Peter J. Roy ()
Additional contact information
Andrew R. Burns: University of Toronto
Rachel J. Baker: University of Toronto
Megan Kitner: USDA-ARS Horticultural Crops Research Laboratory
Jessica Knox: University of Toronto
Brittany Cooke: University of Toronto
Jonathan R. Volpatti: University of Toronto
Aditya S. Vaidya: University of California, Riverside
Emily Puumala: University of Toronto
Bruna M. Palmeira: University of Calgary
Elizabeth M. Redman: University of Calgary
Jamie Snider: University of Toronto
Sagar Marwah: University Health Network
Sai W. Chung: University Health Network
Margaret H. MacDonald: USDA-ARS Mycology and Nematology Genetic Diversity and Biology Laboratory, Beltsville Agricultural Research Center
Jens Tiefenbach: University of Toronto
Chun Hu: University of Toronto
Qi Xiao: University of Calgary
Constance A. M. Finney: University of Calgary
Henry M. Krause: University of Toronto
Sonya A. MacParland: University Health Network
Igor Stagljar: University of Toronto
John S. Gilleard: University of Calgary
Leah E. Cowen: University of Toronto
Susan L. F. Meyer: USDA-ARS Mycology and Nematology Genetic Diversity and Biology Laboratory, Beltsville Agricultural Research Center
Sean R. Cutler: University of California, Riverside
James J. Dowling: University of Toronto
Mark Lautens: University of Toronto
Inga Zasada: USDA-ARS Horticultural Crops Research Laboratory
Peter J. Roy: University of Toronto

Nature, 2023, vol. 618, issue 7963, 102-109

Abstract: Abstract Parasitic nematodes are a major threat to global food security, particularly as the world amasses 10 billion people amid limited arable land1–4. Most traditional nematicides have been banned owing to poor nematode selectivity, leaving farmers with inadequate means of pest control4–12. Here we use the model nematode Caenorhabditis elegans to identify a family of selective imidazothiazole nematicides, called selectivins, that undergo cytochrome-p450-mediated bioactivation in nematodes. At low parts-per-million concentrations, selectivins perform comparably well with commercial nematicides to control root infection by Meloidogyne incognita, a highly destructive plant-parasitic nematode. Tests against numerous phylogenetically diverse non-target systems demonstrate that selectivins are more nematode-selective than most marketed nematicides. Selectivins are first-in-class bioactivated nematode controls that provide efficacy and nematode selectivity.

Date: 2023
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DOI: 10.1038/s41586-023-06105-5

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