 Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancerLuis A. Rojas,
Zachary Sethna,
Kevin C. Soares,
Cristina Olcese,
Nan Pang,
Erin Patterson,
Jayon Lihm,
Nicholas Ceglia,
Pablo Guasp,
Alexander Chu,
Rebecca Yu,
Adrienne Kaya Chandra,
Theresa Waters,
Jennifer Ruan,
Masataka Amisaki,
Abderezak Zebboudj,
Zagaa Odgerel,
George Payne,
Evelyna Derhovanessian,
Felicitas Müller,
Ina Rhee,
Mahesh Yadav,
Anton Dobrin,
Michel Sadelain,
Marta Łuksza,
Noah Cohen,
Laura Tang,
Olca Basturk,
Mithat Gönen,
Seth Katz,
Richard Kinh Do,
Andrew S. Epstein,
Parisa Momtaz,
Wungki Park,
Ryan Sugarman,
Anna M. Varghese,
Elizabeth Won,
Avni Desai,
Alice C. Wei,
Michael I. D’Angelica,
T. Peter Kingham,
Ira Mellman,
Taha Merghoub,
Jedd D. Wolchok,
Ugur Sahin,
Özlem Türeci,
Benjamin D. Greenbaum (),
William R. Jarnagin,
Jeffrey Drebin,
Eileen M. O’Reilly and
Vinod P. Balachandran ()
Nature, 2023, vol. 618, issue 7963, 144-150 Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients1, yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3. Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA neoantigen vaccines in real time from surgically resected PDAC tumours. After surgery, we sequentially administered atezolizumab (an anti-PD-L1 immunotherapy), autogene cevumeran (a maximum of 20 neoantigens per patient) and a modified version of a four-drug chemotherapy regimen (mFOLFIRINOX, comprising folinic acid, fluorouracil, irinotecan and oxaliplatin). The end points included vaccine-induced neoantigen-specific T cells by high-threshold assays, 18-month recurrence-free survival and oncologic feasibility. We treated 16 patients with atezolizumab and autogene cevumeran, then 15 patients with mFOLFIRINOX. Autogene cevumeran was administered within 3 days of benchmarked times, was tolerable and induced de novo high-magnitude neoantigen-specific T cells in 8 out of 16 patients, with half targeting more than one vaccine neoantigen. Using a new mathematical strategy to track T cell clones (CloneTrack) and functional assays, we found that vaccine-expanded T cells comprised up to 10% of all blood T cells, re-expanded with a vaccine booster and included long-lived polyfunctional neoantigen-specific effector CD8+ T cells. At 18-month median follow-up, patients with vaccine-expanded T cells (responders) had a longer median recurrence-free survival (not reached) compared with patients without vaccine-expanded T cells (non-responders; 13.4 months, P = 0.003). Differences in the immune fitness of the patients did not confound this correlation, as responders and non-responders mounted equivalent immunity to a concurrent unrelated mRNA vaccine against SARS-CoV-2. Thus, adjuvant atezolizumab, autogene cevumeran and mFOLFIRINOX induces substantial T cell activity that may correlate with delayed PDAC recurrence. Date: 2023 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:618:y:2023:i:7963:d:10.1038_s41586-023-06063-y Ordering information: This journal article can be ordered from DOI: 10.1038/s41586-023-06063-y Access Statistics for this article Nature is currently edited by Magdalena Skipper More articles in Nature from Nature |
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