Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Gan Sha,
Peng Sun,
Xiaojing Kong,
Xinyu Han,
Qiping Sun,
Laetitia Fouillen,
Juan Zhao,
Yun Li,
Lei Yang,
Yin Wang,
Qiuwen Gong,
Yaru Zhou,
Wenqing Zhou,
Rashmi Jain,
Jie Gao,
Renliang Huang,
Xiaoyang Chen,
Lu Zheng,
Wanying Zhang,
Ziting Qin,
Qi Zhou,
Qingdong Zeng,
Kabin Xie,
Jiandi Xu,
Tsan-Yu Chiu,
Liang Guo,
Jenny C. Mortimer,
Yohann Boutté,
Qiang Li,
Zhensheng Kang,
Pamela C. Ronald () and
Guotian Li ()
Additional contact information
Gan Sha: Huazhong Agricultural University
Peng Sun: Huazhong Agricultural University
Xiaojing Kong: Huazhong Agricultural University
Xinyu Han: Huazhong Agricultural University
Qiping Sun: Huazhong Agricultural University
Laetitia Fouillen: Université de Bordeaux, CNRS
Juan Zhao: Huazhong Agricultural University
Yun Li: Huazhong Agricultural University
Lei Yang: Huazhong Agricultural University
Yin Wang: Huazhong Agricultural University
Qiuwen Gong: Huazhong Agricultural University
Yaru Zhou: Huazhong Agricultural University
Wenqing Zhou: Huazhong Agricultural University
Rashmi Jain: University of California, Davis
Jie Gao: Huazhong Agricultural University
Renliang Huang: Jiangxi Academy of Agricultural Sciences
Xiaoyang Chen: Huazhong Agricultural University
Lu Zheng: Huazhong Agricultural University
Wanying Zhang: Huazhong Agricultural University
Ziting Qin: Huazhong Agricultural University
Qi Zhou: BGI-Shenzhen
Qingdong Zeng: Northwest A&F University
Kabin Xie: Huazhong Agricultural University
Jiandi Xu: Shandong Academy of Agricultural Sciences
Tsan-Yu Chiu: BGI-Shenzhen
Liang Guo: Huazhong Agricultural University
Jenny C. Mortimer: The Joint BioEnergy Institute
Yohann Boutté: Université de Bordeaux, CNRS
Qiang Li: Huazhong Agricultural University
Zhensheng Kang: Northwest A&F University
Pamela C. Ronald: University of California, Davis
Guotian Li: Huazhong Agricultural University
Nature, 2023, vol. 618, issue 7967, 1017-1023
Abstract:
Abstract The discovery and application of genome editing introduced a new era of plant breeding by giving researchers efficient tools for the precise engineering of crop genomes1. Here we demonstrate the power of genome editing for engineering broad-spectrum disease resistance in rice (Oryza sativa). We first isolated a lesion mimic mutant (LMM) from a mutagenized rice population. We then demonstrated that a 29-base-pair deletion in a gene we named RESISTANCE TO BLAST1 (RBL1) caused broad-spectrum disease resistance and showed that this mutation caused an approximately 20-fold reduction in yield. RBL1 encodes a cytidine diphosphate diacylglycerol synthase that is required for phospholipid biosynthesis2. Mutation of RBL1 results in reduced levels of phosphatidylinositol and its derivative phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). In rice, PtdIns(4,5)P2 is enriched in cellular structures that are specifically associated with effector secretion and fungal infection, suggesting that it has a role as a disease-susceptibility factor3. By using targeted genome editing, we obtained an allele of RBL1, named RBL1Δ12, which confers broad-spectrum disease resistance but does not decrease yield in a model rice variety, as assessed in small-scale field trials. Our study has demonstrated the benefits of editing an LMM gene, a strategy relevant to diverse LMM genes and crops.
Date: 2023
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DOI: 10.1038/s41586-023-06205-2
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