DOCK2 is involved in the host genetics and biology of severe COVID-19

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S. Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu-Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B. Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Kazuto Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Koji Sakamoto, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-o, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Kazuhiko Katayama, Masumi Ai, Yoshinori Fukui, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga () and Yukinori Okada ()
Additional contact information
Ho Namkoong: Keio University School of Medicine
Ryuya Edahiro: Osaka University Graduate School of Medicine
Tomomi Takano: Kitasato University
Hiroshi Nishihara: Keio University Hospital
Yuya Shirai: Osaka University Graduate School of Medicine
Kyuto Sonehara: Osaka University Graduate School of Medicine
Hiromu Tanaka: Keio University School of Medicine
Shuhei Azekawa: Keio University School of Medicine
Yohei Mikami: Keio University School of Medicine
Ho Lee: Keio University School of Medicine
Takanori Hasegawa: Tokyo Medical and Dental University
Koji Okudela: Yokohama City University
Daisuke Okuzaki: Osaka University
Daisuke Motooka: Osaka University
Masahiro Kanai: Harvard Medical School
Tatsuhiko Naito: Osaka University Graduate School of Medicine
Kenichi Yamamoto: Osaka University Graduate School of Medicine
Qingbo S. Wang: Osaka University Graduate School of Medicine
Ryunosuke Saiki: Kyoto University
Rino Ishihara: Keio University School of Medicine
Yuta Matsubara: Keio University School of Medicine
Junko Hamamoto: Keio University School of Medicine
Hiroyuki Hayashi: Yokohama Municipal Citizen’s Hospital
Yukihiro Yoshimura: Yokohama Municipal Citizen’s Hospital
Natsuo Tachikawa: Yokohama Municipal Citizen’s Hospital
Emmy Yanagita: Keio University Hospital
Takayoshi Hyugaji: the University of Tokyo
Eigo Shimizu: the University of Tokyo
Kotoe Katayama: the University of Tokyo
Yasuhiro Kato: Osaka University Graduate School of Medicine
Takayoshi Morita: Osaka University Graduate School of Medicine
Kazuhisa Takahashi: Juntendo University Faculty of Medicine and Graduate School of Medicine
Norihiro Harada: Juntendo University Faculty of Medicine and Graduate School of Medicine
Toshio Naito: Juntendo University Faculty of Medicine and Graduate School of Medicine
Makoto Hiki: Juntendo University Faculty of Medicine and Graduate School of Medicine
Yasushi Matsushita: Juntendo University Faculty of Medicine and Graduate School of Medicine
Haruhi Takagi: Juntendo University Faculty of Medicine and Graduate School of Medicine
Ryousuke Aoki: Juntendo University Faculty of Medicine and Graduate School of Medicine
Ai Nakamura: Juntendo University Faculty of Medicine and Graduate School of Medicine
Sonoko Harada: Juntendo University Faculty of Medicine and Graduate School of Medicine
Hitoshi Sasano: Juntendo University Faculty of Medicine and Graduate School of Medicine
Hiroki Kabata: Keio University School of Medicine
Katsunori Masaki: Keio University School of Medicine
Hirofumi Kamata: Keio University School of Medicine
Shinnosuke Ikemura: Keio University School of Medicine
Shotaro Chubachi: Keio University School of Medicine
Satoshi Okamori: Keio University School of Medicine
Hideki Terai: Keio University School of Medicine
Atsuho Morita: Keio University School of Medicine
Takanori Asakura: Keio University School of Medicine
Junichi Sasaki: Keio University School of Medicine
Hiroshi Morisaki: Keio University School of Medicine
Yoshifumi Uwamino: Keio University School of Medicine
Kosaku Nanki: Keio University School of Medicine
Sho Uchida: Keio University School of Medicine
Shunsuke Uno: Keio University School of Medicine
Tomoyasu Nishimura: Keio University School of Medicine
Takashi Ishiguro: Saitama Cardiovascular and Respiratory Center
Taisuke Isono: Saitama Cardiovascular and Respiratory Center
Shun Shibata: Saitama Cardiovascular and Respiratory Center
Yuma Matsui: Saitama Cardiovascular and Respiratory Center
Chiaki Hosoda: Saitama Cardiovascular and Respiratory Center
Kenji Takano: Saitama Cardiovascular and Respiratory Center
Takashi Nishida: Saitama Cardiovascular and Respiratory Center
Yoichi Kobayashi: Saitama Cardiovascular and Respiratory Center
Yotaro Takaku: Saitama Cardiovascular and Respiratory Center
Noboru Takayanagi: Saitama Cardiovascular and Respiratory Center
Soichiro Ueda: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Ai Tada: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Masayoshi Miyawaki: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Masaomi Yamamoto: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Eriko Yoshida: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Reina Hayashi: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Tomoki Nagasaka: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Sawako Arai: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Yutaro Kaneko: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Kana Sasaki: JCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine
Etsuko Tagaya: Tokyo Women’s Medical University
Masatoshi Kawana: Tokyo Women’s Medical University
Ken Arimura: Tokyo Women’s Medical University
Kunihiko Takahashi: Tokyo Medical and Dental University
Tatsuhiko Anzai: Tokyo Medical and Dental University
Satoshi Ito: Tokyo Medical and Dental University
Akifumi Endo: Tokyo Medical and Dental University Hospital of Medicine
Yuji Uchimura: Tokyo Medical and Dental University Hospital of Medicine
Yasunari Miyazaki: Tokyo Medical and Dental University
Takayuki Honda: Tokyo Medical and Dental University
Tomoya Tateishi: Tokyo Medical and Dental University
Shuji Tohda: Tokyo Medical and Dental University Hospital of Medicine
Naoya Ichimura: Tokyo Medical and Dental University Hospital of Medicine
Kazunari Sonobe: Tokyo Medical and Dental University Hospital of Medicine
Chihiro Tani Sassa: Tokyo Medical and Dental University Hospital of Medicine
Jun Nakajima: Tokyo Medical and Dental University Hospital of Medicine
Yasushi Nakano: Department of Internal Medicine
Yukiko Nakajima: Department of Internal Medicine
Ryusuke Anan: Department of Internal Medicine
Ryosuke Arai: Department of Internal Medicine
Yuko Kurihara: Department of Internal Medicine
Yuko Harada: Department of Internal Medicine
Kazumi Nishio: Department of Internal Medicine
Tetsuya Ueda: Osaka Saiseikai Nakatsu Hospital
Masanori Azuma: Osaka Saiseikai Nakatsu Hospital
Ryuichi Saito: Osaka Saiseikai Nakatsu Hospital
Toshikatsu Sado: Osaka Saiseikai Nakatsu Hospital
Yoshimune Miyazaki: Osaka Saiseikai Nakatsu Hospital
Ryuichi Sato: Osaka Saiseikai Nakatsu Hospital
Yuki Haruta: Osaka Saiseikai Nakatsu Hospital
Tadao Nagasaki: Osaka Saiseikai Nakatsu Hospital
Yoshinori Yasui: Osaka Saiseikai Nakatsu Hospital
Yoshinori Hasegawa: Osaka Saiseikai Nakatsu Hospital
Yoshikazu Mutoh: Tosei General Hospital
Tomoki Kimura: Tosei General Hospital
Tomonori Sato: Tosei General Hospital
Reoto Takei: Tosei General Hospital
Satoshi Hagimoto: Tosei General Hospital
Yoichiro Noguchi: Tosei General Hospital
Yasuhiko Yamano: Tosei General Hospital
Hajime Sasano: Tosei General Hospital
Sho Ota: Tosei General Hospital
Yasushi Nakamori: Kansai Medical University General Medical Center
Kazuhisa Yoshiya: Kansai Medical University General Medical Center
Fukuki Saito: Kansai Medical University General Medical Center
Tomoyuki Yoshihara: Kansai Medical University General Medical Center
Daiki Wada: Kansai Medical University General Medical Center
Hiromu Iwamura: Kansai Medical University General Medical Center
Syuji Kanayama: Kansai Medical University General Medical Center
Shuhei Maruyama: Kansai Medical University General Medical Center
Takashi Yoshiyama: Fukujuji hospital
Ken Ohta: Fukujuji hospital
Hiroyuki Kokuto: Fukujuji hospital
Hideo Ogata: Fukujuji hospital
Yoshiaki Tanaka: Fukujuji hospital
Kenichi Arakawa: Fukujuji hospital
Masafumi Shimoda: Fukujuji hospital
Takeshi Osawa: Fukujuji hospital
Hiroki Tateno: Saitama City Hospital
Isano Hase: Saitama City Hospital
Shuichi Yoshida: Saitama City Hospital
Shoji Suzuki: Saitama City Hospital
Miki Kawada: Saitama City Hospital
Hirohisa Horinouchi: Saitama City Hospital
Fumitake Saito: Eiju General Hospital
Keiko Mitamura: Eiju General Hospital
Masao Hagihara: Eiju General Hospital
Junichi Ochi: Eiju General Hospital
Tomoyuki Uchida: Eiju General Hospital
Rie Baba: Saiseikai Utsunomiya Hospital
Daisuke Arai: Saiseikai Utsunomiya Hospital
Takayuki Ogura: Saiseikai Utsunomiya Hospital
Hidenori Takahashi: Saiseikai Utsunomiya Hospital
Shigehiro Hagiwara: Saiseikai Utsunomiya Hospital
Genta Nagao: Saiseikai Utsunomiya Hospital
Shunichiro Konishi: Saiseikai Utsunomiya Hospital
Ichiro Nakachi: Saiseikai Utsunomiya Hospital
Koji Murakami: Tohoku University Graduate School of Medicine
Mitsuhiro Yamada: Tohoku University Graduate School of Medicine
Hisatoshi Sugiura: Tohoku University Graduate School of Medicine
Hirohito Sano: Tohoku University Graduate School of Medicine
Shuichiro Matsumoto: Tohoku University Graduate School of Medicine
Nozomu Kimura: Tohoku University Graduate School of Medicine
Yoshinao Ono: Tohoku University Graduate School of Medicine
Hiroaki Baba: Tohoku University Graduate School of Medicine
Yusuke Suzuki: Kitasato University Kitasato Institute Hospital
Sohei Nakayama: Kitasato University Kitasato Institute Hospital
Keita Masuzawa: Kitasato University Kitasato Institute Hospital
Shinichi Namba: Osaka University Graduate School of Medicine
Ken Suzuki: Osaka University Graduate School of Medicine
Yoko Naito: Osaka University
Yu-Chen Liu: Osaka University
Ayako Takuwa: Osaka University
Fuminori Sugihara: Osaka University
James B. Wing: Osaka University
Shuhei Sakakibara: Osaka University
Nobuyuki Hizawa: University of Tsukuba
Takayuki Shiroyama: Osaka University Graduate School of Medicine
Satoru Miyawaki: the University of Tokyo
Yusuke Kawamura: National Defense Medical College
Akiyoshi Nakayama: National Defense Medical College
Hirotaka Matsuo: National Defense Medical College
Yuichi Maeda: Osaka University Graduate School of Medicine
Takuro Nii: Osaka University Graduate School of Medicine
Yoshimi Noda: Osaka University Graduate School of Medicine
Takayuki Niitsu: Osaka University Graduate School of Medicine
Yuichi Adachi: Osaka University Graduate School of Medicine
Takatoshi Enomoto: Osaka University Graduate School of Medicine
Saori Amiya: Osaka University Graduate School of Medicine
Reina Hara: Osaka University Graduate School of Medicine
Yuta Yamaguchi: Osaka University Graduate School of Medicine
Teruaki Murakami: Osaka University Graduate School of Medicine
Tomoki Kuge: Osaka University Graduate School of Medicine
Kinnosuke Matsumoto: Osaka University Graduate School of Medicine
Yuji Yamamoto: Osaka University Graduate School of Medicine
Makoto Yamamoto: Osaka University Graduate School of Medicine
Midori Yoneda: Osaka University Graduate School of Medicine
Toshihiro Kishikawa: Osaka University Graduate School of Medicine
Shuhei Yamada: Osaka University Graduate School of Medicine
Shuhei Kawabata: Osaka University Graduate School of Medicine
Noriyuki Kijima: Osaka University Graduate School of Medicine
Masatoshi Takagaki: Osaka University Graduate School of Medicine
Noah Sasa: Osaka University Graduate School of Medicine
Yuya Ueno: Osaka University Graduate School of Medicine
Motoyuki Suzuki: Osaka University Graduate School of Medicine
Norihiko Takemoto: Osaka University Graduate School of Medicine
Hirotaka Eguchi: Osaka University Graduate School of Medicine
Takahito Fukusumi: Osaka University Graduate School of Medicine
Takao Imai: Osaka University Graduate School of Medicine
Munehisa Fukushima: Osaka University Graduate School of Medicine
Haruhiko Kishima: Osaka University Graduate School of Medicine
Hidenori Inohara: Osaka University Graduate School of Medicine
Kazunori Tomono: Osaka University Hospital
Kazuto Kato: Osaka University Graduate School of Medicine
Meiko Takahashi: Kyoto University Graduate School of Medicine
Fumihiko Matsuda: Kyoto University Graduate School of Medicine
Haruhiko Hirata: Osaka University Graduate School of Medicine
Yoshito Takeda: Osaka University Graduate School of Medicine
Hidefumi Koh: Tachikawa Hospital
Tadashi Manabe: Tachikawa Hospital
Yohei Funatsu: Tachikawa Hospital
Fumimaro Ito: Tachikawa Hospital
Takahiro Fukui: Tachikawa Hospital
Keisuke Shinozuka: Tachikawa Hospital
Sumiko Kohashi: Tachikawa Hospital
Masatoshi Miyazaki: Tachikawa Hospital
Tomohisa Shoko: Tokyo Women’s Medical University Medical Center East
Mitsuaki Kojima: Tokyo Women’s Medical University Medical Center East
Tomohiro Adachi: Tokyo Women’s Medical University Medical Center East
Motonao Ishikawa: Tokyo Women’s Medical University Medical Center East
Kenichiro Takahashi: Tokyo Women’s Medical University Medical Center East
Takashi Inoue: Sano Kosei General Hospital
Toshiyuki Hirano: Sano Kosei General Hospital
Keigo Kobayashi: Sano Kosei General Hospital
Hatsuyo Takaoka: Sano Kosei General Hospital
Kazuyoshi Watanabe: Kanazawa Hospital
Naoki Miyazawa: Saiseikai Yokohamashi Nanbu Hospital
Yasuhiro Kimura: Saiseikai Yokohamashi Nanbu Hospital
Reiko Sado: Saiseikai Yokohamashi Nanbu Hospital
Hideyasu Sugimoto: Saiseikai Yokohamashi Nanbu Hospital
Akane Kamiya: Saiseikai Yokohamashi Nanbu Hospital
Naota Kuwahara: Showa University Koto Toyosu Hospital
Akiko Fujiwara: Showa University Koto Toyosu Hospital
Tomohiro Matsunaga: Showa University Koto Toyosu Hospital
Yoko Sato: Showa University Koto Toyosu Hospital
Takenori Okada: Showa University Koto Toyosu Hospital
Yoshihiro Hirai: Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital
Hidetoshi Kawashima: Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital
Atsuya Narita: Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital
Kazuki Niwa: Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital
Yoshiyuki Sekikawa: Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital
Koichi Nishi: Ishikawa Prefectural Central Hospital
Masaru Nishitsuji: Ishikawa Prefectural Central Hospital
Mayuko Tani: Ishikawa Prefectural Central Hospital
Junya Suzuki: Ishikawa Prefectural Central Hospital
Hiroki Nakatsumi: Ishikawa Prefectural Central Hospital
Takashi Ogura: Kanagawa Cardiovascular and Respiratory Center
Hideya Kitamura: Kanagawa Cardiovascular and Respiratory Center
Eri Hagiwara: Kanagawa Cardiovascular and Respiratory Center
Kota Murohashi: Kanagawa Cardiovascular and Respiratory Center
Hiroko Okabayashi: Kanagawa Cardiovascular and Respiratory Center
Takao Mochimaru: National Hospital Organization Tokyo Medical Center
Shigenari Nukaga: National Hospital Organization Tokyo Medical Center
Ryosuke Satomi: National Hospital Organization Tokyo Medical Center
Yoshitaka Oyamada: National Hospital Organization Tokyo Medical Center
Nobuaki Mori: National Hospital Organization Tokyo Medical Center
Tomoya Baba: Toyohashi Municipal Hospital
Yasutaka Fukui: Toyohashi Municipal Hospital
Mitsuru Odate: Toyohashi Municipal Hospital
Shuko Mashimo: Toyohashi Municipal Hospital
Yasushi Makino: Toyohashi Municipal Hospital
Kazuma Yagi: Keiyu Hospital
Mizuha Hashiguchi: Keiyu Hospital
Junko Kagyo: Keiyu Hospital
Tetsuya Shiomi: Keiyu Hospital
Satoshi Fuke: KKR Sapporo Medical Center
Hiroshi Saito: KKR Sapporo Medical Center
Tomoya Tsuchida: St Marianna University School of Medicine
Shigeki Fujitani: St Marianna University School of Medicine
Mumon Takita: St Marianna University School of Medicine
Daiki Morikawa: St Marianna University School of Medicine
Toru Yoshida: St Marianna University School of Medicine
Takehiro Izumo: Japanese Red Cross Medical Center
Minoru Inomata: Japanese Red Cross Medical Center
Naoyuki Kuse: Japanese Red Cross Medical Center
Nobuyasu Awano: Japanese Red Cross Medical Center
Mari Tone: Japanese Red Cross Medical Center
Akihiro Ito: Matsumoto City Hospital
Yoshihiko Nakamura: Fukuoka University
Kota Hoshino: Fukuoka University
Junichi Maruyama: Fukuoka University
Hiroyasu Ishikura: Fukuoka University
Tohru Takata: Fukuoka University Hospital
Toshio Odani: National Hospital Organization Hokkaido Medical Center
Masaru Amishima: National Hospital Organization Hokkaido Medical Center
Takeshi Hattori: National Hospital Organization Hokkaido Medical Center
Yasuo Shichinohe: National Hospital Organization Hokkaido Medical Center
Takashi Kagaya: National Hospital Organization Kanazawa Medical Center
Toshiyuki Kita: National Hospital Organization Kanazawa Medical Center
Kazuhide Ohta: National Hospital Organization Kanazawa Medical Center
Satoru Sakagami: National Hospital Organization Kanazawa Medical Center
Kiyoshi Koshida: National Hospital Organization Kanazawa Medical Center
Kentaro Hayashi: Division of Respiratory Medicine
Tetsuo Shimizu: Division of Respiratory Medicine
Yutaka Kozu: Division of Respiratory Medicine
Hisato Hiranuma: Division of Respiratory Medicine
Yasuhiro Gon: Division of Respiratory Medicine
Namiki Izumi: Musashino Red Cross Hospital
Kaoru Nagata: Musashino Red Cross Hospital
Ken Ueda: Musashino Red Cross Hospital
Reiko Taki: Musashino Red Cross Hospital
Satoko Hanada: Musashino Red Cross Hospital
Kodai Kawamura: Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital
Kazuya Ichikado: Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital
Kenta Nishiyama: Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital
Hiroyuki Muranaka: Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital
Kazunori Nakamura: Division of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital
Naozumi Hashimoto: Nagoya University Graduate School of Medicine
Keiko Wakahara: Nagoya University Graduate School of Medicine
Koji Sakamoto: Nagoya University Graduate School of Medicine
Norihito Omote: Nagoya University Graduate School of Medicine
Akira Ando: Nagoya University Graduate School of Medicine
Nobuhiro Kodama: Fukuoka Tokushukai Hospital
Yasunari Kaneyama: Fukuoka Tokushukai Hospital
Shunsuke Maeda: Fukuoka Tokushukai Hospital
Takashige Kuraki: Fukuoka Tokushukai Hospital
Takemasa Matsumoto: Fukuoka Tokushukai Hospital
Koutaro Yokote: Chiba University Graduate School of Medicine
Taka-Aki Nakada: Chiba University Graduate School of Medicine
Ryuzo Abe: Chiba University Graduate School of Medicine
Taku Oshima: Chiba University Graduate School of Medicine
Tadanaga Shimada: Chiba University Graduate School of Medicine
Masahiro Harada: National Hospital Organization Kumamoto Medical Center
Takeshi Takahashi: National Hospital Organization Kumamoto Medical Center
Hiroshi Ono: National Hospital Organization Kumamoto Medical Center
Toshihiro Sakurai: National Hospital Organization Kumamoto Medical Center
Takayuki Shibusawa: National Hospital Organization Kumamoto Medical Center
Yoshifumi Kimizuka: National Defense Medical College
Akihiko Kawana: National Defense Medical College
Tomoya Sano: National Defense Medical College
Chie Watanabe: National Defense Medical College
Ryohei Suematsu: National Defense Medical College
Hisako Sageshima: Sapporo City General Hospital
Ayumi Yoshifuji: Tokyo Saiseikai Central Hospital
Kazuto Ito: Tokyo Saiseikai Central Hospital
Saeko Takahashi: Tokyo Saiseikai Central Hospital
Kota Ishioka: Tokyo Saiseikai Central Hospital
Morio Nakamura: Tokyo Saiseikai Central Hospital
Makoto Masuda: Fujisawa City Hospital
Aya Wakabayashi: Fujisawa City Hospital
Hiroki Watanabe: Fujisawa City Hospital
Suguru Ueda: Fujisawa City Hospital
Masanori Nishikawa: Fujisawa City Hospital
Yusuke Chihara: Uji-Tokushukai Medical Center
Mayumi Takeuchi: Uji-Tokushukai Medical Center
Keisuke Onoi: Uji-Tokushukai Medical Center
Jun Shinozuka: Uji-Tokushukai Medical Center
Atsushi Sueyoshi: Uji-Tokushukai Medical Center
Yoji Nagasaki: National Hospital Organization Kyushu Medical Center
Masaki Okamoto: National Hospital Organization Kyushu Medical Center
Sayoko Ishihara: National Hospital Organization Kyushu Medical Center
Masatoshi Shimo: National Hospital Organization Kyushu Medical Center
Yoshihisa Tokunaga: National Hospital Organization Kyushu Medical Center
Yu Kusaka: Ome Municipal General Hospital
Takehiko Ohba: Ome Municipal General Hospital
Susumu Isogai: Ome Municipal General Hospital
Aki Ogawa: Ome Municipal General Hospital
Takuya Inoue: Ome Municipal General Hospital
Satoru Fukuyama: Kyushu University
Yoshihiro Eriguchi: Kyushu University Graduate School of Medical Sciences
Akiko Yonekawa: Kyushu University Graduate School of Medical Sciences
Keiko Kan-o: Kyushu University
Koichiro Matsumoto: Kyushu University
Kensuke Kanaoka: Daini Osaka Police Hospital
Shoichi Ihara: Daini Osaka Police Hospital
Kiyoshi Komuta: Daini Osaka Police Hospital
Yoshiaki Inoue: University of Tsukuba
Shigeru Chiba: University of Tsukuba
Kunihiro Yamagata: University of Tsukuba
Yuji Hiramatsu: University of Tsukuba
Hirayasu Kai: University of Tsukuba
Koichiro Asano: Tokai University School of Medicine
Tsuyoshi Oguma: Tokai University School of Medicine
Yoko Ito: Tokai University School of Medicine
Satoru Hashimoto: Kyoto Prefectural University of Medicine
Masaki Yamasaki: Kyoto Prefectural University of Medicine
Yu Kasamatsu: Kyoto Prefectural University of Medicine
Yuko Komase: St Marianna University School of Medicine, Yokohama Seibu Hospital
Naoya Hida: St Marianna University School of Medicine, Yokohama Seibu Hospital
Takahiro Tsuburai: St Marianna University School of Medicine, Yokohama Seibu Hospital
Baku Oyama: St Marianna University School of Medicine, Yokohama Seibu Hospital
Minoru Takada: The Second Hospital
Hidenori Kanda: The Second Hospital
Yuichiro Kitagawa: Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine
Tetsuya Fukuta: Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine
Takahito Miyake: Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine
Shozo Yoshida: Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine
Shinji Ogura: Gifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine
Shinji Abe: Tokyo Medical University Hospital
Yuta Kono: Tokyo Medical University Hospital
Yuki Togashi: Tokyo Medical University Hospital
Hiroyuki Takoi: Tokyo Medical University Hospital
Ryota Kikuchi: Tokyo Medical University Hospital
Shinichi Ogawa: JA Toride Medical Hospital
Tomouki Ogata: JA Toride Medical Hospital
Shoichiro Ishihara: JA Toride Medical Hospital
Arihiko Kanehiro: Okayama Rosai Hospital
Shinji Ozaki: Okayama Rosai Hospital
Yasuko Fuchimoto: Okayama Rosai Hospital
Sae Wada: Okayama Rosai Hospital
Nobukazu Fujimoto: Okayama Rosai Hospital
Kei Nishiyama: Emergency and Critical Care, Niigata University
Mariko Terashima: Emergency and Critical Care Center, National Hospital Organization Kyoto Medical Center
Satoru Beppu: Emergency and Critical Care Center, National Hospital Organization Kyoto Medical Center
Kosuke Yoshida: Emergency and Critical Care Center, National Hospital Organization Kyoto Medical Center
Osamu Narumoto: National Hospital Organization Tokyo Hospital Hospital
Hideaki Nagai: National Hospital Organization Tokyo Hospital Hospital
Nobuharu Ooshima: National Hospital Organization Tokyo Hospital Hospital
Mitsuru Motegi: Fujioka General Hospital
Akira Umeda: International University of Health and Welfare Shioya Hospital
Kazuya Miyagawa: International University of Health and Welfare
Hisato Shimada: International University of Health and Welfare Shioya Hospital
Mayu Endo: International University of Health and Welfare Shioya Hospital
Yoshiyuki Ohira: International University of Health and Welfare Shioya Hospital
Masafumi Watanabe: Yamagata University Faculty of Medicine
Sumito Inoue: Yamagata University Faculty of Medicine
Akira Igarashi: Yamagata University Faculty of Medicine
Masamichi Sato: Yamagata University Faculty of Medicine
Hironori Sagara: Showa University
Akihiko Tanaka: Showa University
Shin Ohta: Showa University
Tomoyuki Kimura: Showa University
Yoko Shibata: Fukushima Medical University
Yoshinori Tanino: Fukushima Medical University
Takefumi Nikaido: Fukushima Medical University
Hiroyuki Minemura: Fukushima Medical University
Yuki Sato: Fukushima Medical University
Yuichiro Yamada: Kansai Electric Power Hospital
Takuya Hashino: Kansai Electric Power Hospital
Masato Shinoki: Kansai Electric Power Hospital
Hajime Iwagoe: Kumamoto City Hospital
Hiroshi Takahashi: Kumamoto City Hospital
Kazuhiko Fujii: Kumamoto City Hospital
Hiroto Kishi: Kumamoto City Hospital
Masayuki Kanai: Tokyo Metropolitan Police Hospital
Tomonori Imamura: Tokyo Metropolitan Police Hospital
Tatsuya Yamashita: Tokyo Metropolitan Police Hospital
Masakiyo Yatomi: Gunma University Graduate School of Medicine
Toshitaka Maeno: Gunma University Graduate School of Medicine
Shinichi Hayashi: National Hospital Organization Saitama Hospital
Mai Takahashi: National Hospital Organization Saitama Hospital
Mizuki Kuramochi: National Hospital Organization Saitama Hospital
Isamu Kamimaki: National Hospital Organization Saitama Hospital
Yoshiteru Tominaga: National Hospital Organization Saitama Hospital
Tomoo Ishii: Tokyo Medical University Ibaraki Medical Center
Mitsuyoshi Utsugi: Kiryu Kosei General Hospital
Akihiro Ono: Kiryu Kosei General Hospital
Toru Tanaka: Graduate School of Medicine, Nippon Medical School
Takeru Kashiwada: Graduate School of Medicine, Nippon Medical School
Kazue Fujita: Graduate School of Medicine, Nippon Medical School
Yoshinobu Saito: Graduate School of Medicine, Nippon Medical School
Masahiro Seike: Graduate School of Medicine, Nippon Medical School
Hiroko Watanabe: Tsukuba Kinen General Hospital
Hiroto Matsuse: Toho University Ohashi Medical Center
Norio Kodaka: Toho University Ohashi Medical Center
Chihiro Nakano: Toho University Ohashi Medical Center
Takeshi Oshio: Toho University Ohashi Medical Center
Takatomo Hirouchi: Toho University Ohashi Medical Center
Shohei Makino: Kobe University Graduate School of Medicine
Moritoki Egi: Kobe University Graduate School of Medicine
Yosuke Omae: National Center for Global Health and Medicine
Yasuhito Nannya: Kyoto University
Takafumi Ueno: Tokyo Institute of Technology
Kazuhiko Katayama: Kitasato University
Masumi Ai: Tokyo Medical and Dental University Hospital of Medicine
Yoshinori Fukui: Kyushu University
Atsushi Kumanogoh: Osaka University Graduate School of Medicine
Toshiro Sato: Keio University School of Medicine
Naoki Hasegawa: Keio University School of Medicine
Katsushi Tokunaga: National Center for Global Health and Medicine
Makoto Ishii: Keio University School of Medicine
Ryuji Koike: Tokyo Medical and Dental University
Yuko Kitagawa: Keio University School of Medicine
Akinori Kimura: Tokyo Medical and Dental University
Seiya Imoto: the University of Tokyo
Satoru Miyano: Tokyo Medical and Dental University
Seishi Ogawa: Kyoto University
Takanori Kanai: Keio University School of Medicine
Koichi Fukunaga: Keio University School of Medicine
Yukinori Okada: Osaka University Graduate School of Medicine

Nature, 2022, vol. 609, issue 7928, 754-760

Abstract: Abstract Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1–5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.

Date: 2022
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DOI: 10.1038/s41586-022-05163-5

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