RETRACTED ARTICLE: Intrinsically unidirectional chemically fuelled rotary molecular motors

Ke Mo, Yu Zhang, Zheng Dong, Yuhang Yang, Xiaoqiang Ma, Ben L. Feringa () and Depeng Zhao ()
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Ke Mo: Sun Yat-Sen University
Yu Zhang: Sun Yat-Sen University
Zheng Dong: Sun Yat-Sen University
Yuhang Yang: Sun Yat-Sen University
Xiaoqiang Ma: Sun Yat-Sen University
Ben L. Feringa: University of Groningen
Depeng Zhao: Sun Yat-Sen University

Nature, 2022, vol. 609, issue 7926, 293-298

Abstract: Abstract Biological systems mainly utilize chemical energy to fuel autonomous molecular motors, enabling the system to be driven out of equilibrium1. Taking inspiration from rotary motors such as the bacterial flagellar motor2 and adenosine triphosphate synthase3, and building on the success of light-powered unidirectional rotary molecular motors4–6, scientists have pursued the design of synthetic molecular motors solely driven by chemical energy7–13. However, designing artificial rotary molecular motors operating autonomously using a chemical fuel and simultaneously featuring the intrinsic structural design elements to allow full 360° unidirectional rotary motion like adenosine triphosphate synthase remains challenging. Here we show that a homochiral biaryl Motor-3, with three distinct stereochemical elements, is a rotary motor that undergoes repetitive and unidirectional 360° rotation of the two aryl groups around a single-bond axle driven by a chemical fuel. It undergoes sequential ester cyclization, helix inversion and ring opening, and up to 99% unidirectionality is realized over the autonomous rotary cycle. The molecular rotary motor can be operated in two modes: synchronized motion with pulses of a chemical fuel and acid–base oscillations; and autonomous motion in the presence of a chemical fuel under slightly basic aqueous conditions. This rotary motor design with intrinsic control over the direction of rotation, simple chemical fuelling for autonomous motion and near-perfect unidirectionality illustrates the potential for future generations of multicomponent machines to perform mechanical functions.

Date: 2022
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DOI: 10.1038/s41586-022-05033-0

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