 Longitudinal multi-omics of host–microbe dynamics in prediabetesWenyu Zhou,
M. Reza Sailani,
Kévin Contrepois,
Yanjiao Zhou,
Sara Ahadi,
Shana R. Leopold,
Martin J. Zhang,
Varsha Rao,
Monika Avina,
Tejaswini Mishra,
Jethro Johnson,
Brittany Lee-McMullen,
Songjie Chen,
Ahmed A. Metwally,
Thi Dong Binh Tran,
Hoan Nguyen,
Xin Zhou,
Brandon Albright,
Bo-Young Hong,
Lauren Petersen,
Eddy Bautista,
Blake Hanson,
Lei Chen,
Daniel Spakowicz,
Amir Bahmani,
Denis Salins,
Benjamin Leopold,
Melanie Ashland,
Orit Dagan-Rosenfeld,
Shannon Rego,
Patricia Limcaoco,
Elizabeth Colbert,
Candice Allister,
Dalia Perelman,
Colleen Craig,
Eric Wei,
Hassan Chaib,
Daniel Hornburg,
Jessilyn Dunn,
Liang Liang,
Sophia Miryam Schüssler-Fiorenza Rose,
Kim Kukurba,
Brian Piening,
Hannes Rost,
David Tse,
Tracey McLaughlin,
Erica Sodergren,
George M. Weinstock () and
Michael Snyder ()
Nature, 2019, vol. 569, issue 7758, 663-671 Abstract: Abstract Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set revealed many insights: first, healthy profiles are distinct among individuals while displaying diverse patterns of intra- and/or inter-personal variability. Second, extensive host and microbial changes occur during respiratory viral infections and immunization, and immunization triggers potentially protective responses that are distinct from responses to respiratory viral infections. Moreover, during respiratory viral infections, insulin-resistant participants respond differently than insulin-sensitive participants. Third, global co-association analyses among the thousands of profiled molecules reveal specific host–microbe interactions that differ between insulin-resistant and insulin-sensitive individuals. Last, we identified early personal molecular signatures in one individual that preceded the onset of T2D, including the inflammation markers interleukin-1 receptor agonist (IL-1RA) and high-sensitivity C-reactive protein (CRP) paired with xenobiotic-induced immune signalling. Our study reveals insights into pathways and responses that differ between glucose-dysregulated and healthy individuals during health and disease and provides an open-access data resource to enable further research into healthy, prediabetic and T2D states. Date: 2019 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:569:y:2019:i:7758:d:10.1038_s41586-019-1236-x Ordering information: This journal article can be ordered from DOI: 10.1038/s41586-019-1236-x Access Statistics for this article Nature is currently edited by Magdalena Skipper More articles in Nature from Nature |
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