Comparative analysis of regulatory information and circuits across distant species

Alan P. Boyle, Carlos L. Araya, Cathleen Brdlik, Philip Cayting, Chao Cheng, Yong Cheng, Kathryn Gardner, LaDeana W. Hillier, Judith Janette, Lixia Jiang, Dionna Kasper, Trupti Kawli, Pouya Kheradpour, Anshul Kundaje, Jingyi Jessica Li, Lijia Ma, Wei Niu, E. Jay Rehm, Joel Rozowsky, Matthew Slattery, Rebecca Spokony, Robert Terrell, Dionne Vafeados, Daifeng Wang, Peter Weisdepp, Yi-Chieh Wu, Dan Xie, Koon-Kiu Yan, Elise A. Feingold, Peter J. Good, Michael J. Pazin, Haiyan Huang, Peter J. Bickel, Steven E. Brenner, Valerie Reinke, Robert H. Waterston, Mark Gerstein, Kevin P. White (), Manolis Kellis () and Michael Snyder ()
Additional contact information
Alan P. Boyle: Stanford University School of Medicine
Carlos L. Araya: Stanford University School of Medicine
Cathleen Brdlik: Stanford University School of Medicine
Philip Cayting: Stanford University School of Medicine
Chao Cheng: Program of Computational Biology and Bioinformatics, Yale University
Yong Cheng: Stanford University School of Medicine
Kathryn Gardner: Yale University School of Medicine
LaDeana W. Hillier: University of Washington
Judith Janette: Yale University School of Medicine
Lixia Jiang: Stanford University School of Medicine
Dionna Kasper: Yale University School of Medicine
Trupti Kawli: Stanford University School of Medicine
Pouya Kheradpour: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
Anshul Kundaje: Stanford University
Jingyi Jessica Li: University of California
Lijia Ma: University of Washington
Wei Niu: Yale University School of Medicine
E. Jay Rehm: Institute for Genomics and Systems Biology, University of Chicago
Joel Rozowsky: Program of Computational Biology and Bioinformatics, Yale University
Matthew Slattery: Institute for Genomics and Systems Biology, University of Chicago
Rebecca Spokony: Institute for Genomics and Systems Biology, University of Chicago
Robert Terrell: University of Washington
Dionne Vafeados: University of Washington
Daifeng Wang: Program of Computational Biology and Bioinformatics, Yale University
Peter Weisdepp: University of Washington
Yi-Chieh Wu: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
Dan Xie: Stanford University School of Medicine
Koon-Kiu Yan: Program of Computational Biology and Bioinformatics, Yale University
Elise A. Feingold: National Human Genome Research Institute, National Institutes of Health
Peter J. Good: National Human Genome Research Institute, National Institutes of Health
Michael J. Pazin: National Human Genome Research Institute, National Institutes of Health
Haiyan Huang: University of California
Peter J. Bickel: University of California
Steven E. Brenner: University of California
Valerie Reinke: Yale University School of Medicine
Robert H. Waterston: University of Washington
Mark Gerstein: Program of Computational Biology and Bioinformatics, Yale University
Kevin P. White: Institute for Genomics and Systems Biology, University of Chicago
Manolis Kellis: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
Michael Snyder: Stanford University School of Medicine

Nature, 2014, vol. 512, issue 7515, 453-456

Abstract: A map of genome-wide binding locations of 165 human, 93 worm and 52 fly transcription-regulatory factors (almost 50% presented for the first time) from diverse cell types, developmental stages, or conditions reveals that gene-regulatory properties previously observed for individual factors may be general principles of metazoan regulation that are well preserved.

Date: 2014
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DOI: 10.1038/nature13668

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