Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Isao Kobayashi, Jingjing Kobayashi-Sun, Albert D. Kim, Claire Pouget, Naonobu Fujita, Toshio Suda and David Traver ()
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Isao Kobayashi: University of California, San Diego, La Jolla, California 92093-0380, USA
Jingjing Kobayashi-Sun: University of California, San Diego, La Jolla, California 92093-0380, USA
Albert D. Kim: University of California, San Diego, La Jolla, California 92093-0380, USA
Claire Pouget: University of California, San Diego, La Jolla, California 92093-0380, USA
Naonobu Fujita: Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093-0380, USA
Toshio Suda: The Sakaguchi Laboratory, School of Medicine, Keio University, Shinjukuku, Tokyo 160-8582, Japan
David Traver: University of California, San Diego, La Jolla, California 92093-0380, USA

Nature, 2014, vol. 512, issue 7514, 319-323

Abstract: Notch signalling has a key role in the generation of haematopoietic stem cells (HSCs) during vertebrate development; here two adhesion molecules, Jam1a and Jam2a, are shown to be essential for the contact between precursors of HSCs and the somite during embryonic migration, and the Jam1a–Jam2a interaction is shown to be needed to transmit the Notch signal and produce HSCs.

Date: 2014
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DOI: 10.1038/nature13623

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