Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport

Sayan Gupta, Jin Chai, Jie Cheng, Rhijuta D’Mello, Mark R. Chance () and Dax Fu ()
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Sayan Gupta: Center for Synchrotron Biosciences and Center for Proteomics and Bioinformatics, Case Western Reserve University
Jin Chai: Brookhaven National Laboratory
Jie Cheng: Johns Hopkins School of Medicine
Rhijuta D’Mello: Center for Synchrotron Biosciences and Center for Proteomics and Bioinformatics, Case Western Reserve University
Mark R. Chance: Center for Synchrotron Biosciences and Center for Proteomics and Bioinformatics, Case Western Reserve University
Dax Fu: Brookhaven National Laboratory

Nature, 2014, vol. 512, issue 7512, 101-104

Abstract: In the transport cycle of Yiip, zinc(ii) binding triggers a highly localized, all-or-nothing change of water accessibility to the transport site and an adjacent hydrophobic gate.

Date: 2014
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DOI: 10.1038/nature13382

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