Dynamic pathways of −1 translational frameshifting

Jin Chen, Alexey Petrov, Magnus Johansson, Albert Tsai, Seán E. O’Leary and Joseph D. Puglisi ()
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Jin Chen: Stanford University
Alexey Petrov: Stanford University School of Medicine
Magnus Johansson: Stanford University School of Medicine
Albert Tsai: Stanford University
Seán E. O’Leary: Stanford University School of Medicine
Joseph D. Puglisi: Stanford University School of Medicine

Nature, 2014, vol. 512, issue 7514, 328-332

Abstract: To investigate the mechanism of frameshifting during messenger RNA translation, a technique was developed to monitor translation of single molecules in real time using Förster resonance energy transfer (FRET); ribosomes were revealed to pause tenfold longer than usual during elongation at the frameshifting sites.

Date: 2014
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DOI: 10.1038/nature13428

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