Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

Lorena Arranz, Abel Sánchez-Aguilera, Daniel Martín-Pérez, Joan Isern, Xavier Langa, Alexandar Tzankov, Pontus Lundberg, Sandra Muntión, Yi-Shiuan Tzeng, Dar-Ming Lai, Jürg Schwaller, Radek C. Skoda and Simón Méndez-Ferrer ()
Additional contact information
Lorena Arranz: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Abel Sánchez-Aguilera: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Daniel Martín-Pérez: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Joan Isern: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Xavier Langa: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
Alexandar Tzankov: University Hospital Basel, CH-4031 Basel, Switzerland
Pontus Lundberg: University Hospital Basel, CH-4031 Basel, Switzerland
Sandra Muntión: IBSAL-Hospital Universitario de Salamanca, 37007 Salamanca, Spain
Yi-Shiuan Tzeng: National Taiwan University, Taipei 10002, Taiwan
Dar-Ming Lai: National Taiwan University, Taipei 10002, Taiwan
Jürg Schwaller: University Hospital Basel, CH-4031 Basel, Switzerland
Radek C. Skoda: University Hospital Basel, CH-4031 Basel, Switzerland
Simón Méndez-Ferrer: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain

Nature, 2014, vol. 512, issue 7512, 78-81

Abstract: Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

Date: 2014
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DOI: 10.1038/nature13383

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