Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

Phong Dang Nguyen, Georgina Elizabeth Hollway, Carmen Sonntag, Lee Barry Miles, Thomas Edward Hall, Silke Berger, Kristine Joy Fernandez, David Baruch Gurevich, Nicholas James Cole, Sara Alaei, Mirana Ramialison, Robert Lyndsay Sutherland, Jose Maria Polo, Graham John Lieschke and Peter David Currie ()
Additional contact information
Phong Dang Nguyen: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Georgina Elizabeth Hollway: The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia
Carmen Sonntag: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Lee Barry Miles: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Thomas Edward Hall: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Silke Berger: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Kristine Joy Fernandez: The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia
David Baruch Gurevich: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Nicholas James Cole: University of Sydney Medical School Anderson Stuart Building University of Sydney
Sara Alaei: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Mirana Ramialison: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Robert Lyndsay Sutherland: The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia
Jose Maria Polo: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Graham John Lieschke: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Peter David Currie: Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia

Nature, 2014, vol. 512, issue 7514, 314-318

Abstract: A new somite compartment, called the endotome, that contributes to the formation of the embryonic dorsal aorta by providing endothelial progenitors is identified here; endotome-derived endothelial progenitors, whose formation is regulated by the activity of the meox1 gene, induce haematopoietic stem cell formation upon colonization of the nascent dorsal aorta.

Date: 2014
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DOI: 10.1038/nature13678

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