A vaccine targeting mutant IDH1 induces antitumour immunity

Theresa Schumacher, Lukas Bunse, Stefan Pusch, Felix Sahm, Benedikt Wiestler, Jasmin Quandt, Oliver Menn, Matthias Osswald, Iris Oezen, Martina Ott, Melanie Keil, Jörg Balß, Katharina Rauschenbach, Agnieszka K. Grabowska, Isabel Vogler, Jan Diekmann, Nico Trautwein, Stefan B. Eichmüller, Jürgen Okun, Stefan Stevanović, Angelika B. Riemer, Ugur Sahin, Manuel A. Friese, Philipp Beckhove, Andreas von Deimling, Wolfgang Wick and Michael Platten ()
Additional contact information
Theresa Schumacher: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Lukas Bunse: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Stefan Pusch: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Felix Sahm: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Benedikt Wiestler: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Jasmin Quandt: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Oliver Menn: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Matthias Osswald: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Iris Oezen: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Martina Ott: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Melanie Keil: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Jörg Balß: German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Katharina Rauschenbach: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Agnieszka K. Grabowska: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Isabel Vogler: Ribological GmbH, 55131 Mainz, Germany
Jan Diekmann: Translational Oncology, 55131 Mainz, Germany
Nico Trautwein: University of Tübingen, 72076 Tübingen, Germany
Stefan B. Eichmüller: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Jürgen Okun: Metabolic Centre Heidelberg, University Children’s Hospital, 69120 Heidelberg, Germany
Stefan Stevanović: University of Tübingen, 72076 Tübingen, Germany
Angelika B. Riemer: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Ugur Sahin: Translational Oncology, 55131 Mainz, Germany
Manuel A. Friese: Center for Molecular Neurobiology, University Medical Center, Hamburg-Eppendorf, 20251 Hamburg, Germany
Philipp Beckhove: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Andreas von Deimling: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Wolfgang Wick: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
Michael Platten: University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany

Nature, 2014, vol. 512, issue 7514, 324-327

Abstract: The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner.

Date: 2014
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DOI: 10.1038/nature13387

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