DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

Sibylle Schleich, Katrin Strassburger, Philipp Christoph Janiesch, Tatyana Koledachkina, Katharine K. Miller, Katharina Haneke, Yong-Sheng Cheng, Katrin Küchler, Georg Stoecklin, Kent E. Duncan () and Aurelio A. Teleman ()
Additional contact information
Sibylle Schleich: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Katrin Strassburger: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Philipp Christoph Janiesch: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany
Tatyana Koledachkina: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany
Katharine K. Miller: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany
Katharina Haneke: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Yong-Sheng Cheng: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Katrin Küchler: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany
Georg Stoecklin: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Kent E. Duncan: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany
Aurelio A. Teleman: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

Nature, 2014, vol. 512, issue 7513, 208-212

Abstract: This study identifies the DENR–MCT-1 complex as the first factors in animals specific for translation re-initiation downstream of upstream Open Reading Frames (uORFs).

Date: 2014
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DOI: 10.1038/nature13401

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