Zylka et al. reply

Mark J. Zylka (), Ben D. Philpot and Ian F. King
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Mark J. Zylka: The University of North Carolina at Chapel Hill
Ben D. Philpot: The University of North Carolina at Chapel Hill
Ian F. King: The University of North Carolina at Chapel Hill

Nature, 2014, vol. 512, issue 7512, E2-E2

Abstract: Abstract Replying to S. Shohat & S. Shifman Nature 512, 10.1038/nature13583 (2014) Shohat and Shifman’s analysis1 indicates that long autism spectrum disorder (ASD) genes are overrepresented in the SFARI Gene/AutDB database (as of 11 December 2013) owing to the discovery method. We agree with their analysis and with the need to consider the strength of evidence behind each candidate gene. When our study was underway2, SFARI Gene provided the only comprehensive list of autism candidate genes with confidence values. Subsequent to our publication, more genes have been added to this database and scored, highlighting the rapid pace of advances in the ASD field and the changing confidence behind each ASD gene.

Date: 2014
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DOI: 10.1038/nature13584

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