Historical contingency and its biophysical basis in glucocorticoid receptor evolution

Michael J. Harms and Joseph W. Thornton ()
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Michael J. Harms: University of Oregon
Joseph W. Thornton: University of Chicago

Nature, 2014, vol. 512, issue 7513, 203-207

Abstract: By characterizing a very large number of might-have-been evolutionary trajectories starting from a resurrected ancestral protein, the authors show that the evolution of an essential modern protein was contingent on extremely unlikely historical mutations.

Date: 2014
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DOI: 10.1038/nature13410

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