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Genome-scale functional characterization of Drosophila developmental enhancers in vivo

Evgeny Z. Kvon, Tomas Kazmar, Gerald Stampfel, J. Omar Yáñez-Cuna, Michaela Pagani, Katharina Schernhuber, Barry J. Dickson and Alexander Stark ()
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Evgeny Z. Kvon: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Tomas Kazmar: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Gerald Stampfel: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
J. Omar Yáñez-Cuna: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Michaela Pagani: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Katharina Schernhuber: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Barry J. Dickson: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Alexander Stark: Research Institute of Molecular Pathology (IMP), Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria

Nature, 2014, vol. 512, issue 7512, 91-95

Abstract: Systematically assaying the activity of 7,705 candidate enhancers during Drosophila embryogenesis shows that nearly half are active in the embryo and display dynamic spatial patterns during development; enhancer activity is matched to expression patterns of putative target genes and predictive cis-regulatory motifs are identified.

Date: 2014
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DOI: 10.1038/nature13395

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