The Drosophila protein Wunen repels migrating germ cells

Nian Zhang, Jiaping Zhang, Karen J. Purcell, Yan Cheng and Ken Howard
Additional contact information
Nian Zhang: The Jackson Laboratory
Jiaping Zhang: Roche Research Center
Karen J. Purcell: Yale University School of Medicine, Departments of Cell Biology and Biology
Yan Cheng: Roche Research Center
Ken Howard: Roche Research Center

Nature, 1997, vol. 385, issue 6611, 64-67

Abstract: Abstract INDrosophila, germ cells migrate in embryonic development from the lumen of the developing gut towards the overlying mesoderm, where they enter the gonads1,2. The gene wunen is responsible for guiding the germ cells early in this process3. Here we report that the protein Wunen has two properties that allow it to use repulsion to guide the germ cells. Wunen can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm. Wunen shows strong similarity to the enzyme type 2 phosphatidic acid phophatase(PAP2)4, suggesting that it is involved in lipid metabolism.

Date: 1997
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DOI: 10.1038/385064a0

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