A role for Cajal–Retzius cells and reelin in the development of hippocampal connections

José A. Del Río, Bernd Heimrich, Víctor Borrell, Eckart Förster, Alexander Drakew, Soledad Alcántara, Kazunori Nakajima, Takaki Miyata, Masaharu Ogawa, Katsuhiko Mikoshiba, Paul Derer, Michael Frotscher and Eduardo Soriano
Additional contact information
José A. Del Río: University of Barcelona
Bernd Heimrich: University of Freiburg
Víctor Borrell: University of Barcelona
Eckart Förster: University of Freiburg
Alexander Drakew: University of Freiburg
Soledad Alcántara: University of Barcelona
Kazunori Nakajima: The Institute of Physical and Chemical Research (RIKEN)
Takaki Miyata: The Institute of Physical and Chemical Research (RIKEN)
Masaharu Ogawa: Kochi Medical School
Katsuhiko Mikoshiba: The Institute of Physical and Chemical Research (RIKEN)
Paul Derer: Pierre et Marie Curie University
Michael Frotscher: University of Freiburg
Eduardo Soriano: University of Barcelona

Nature, 1997, vol. 385, issue 6611, 70-74

Abstract: Abstract DURING development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate1–4. In the hippocampus, distinct groups of fibres innervate different layers5. We have tested the hypothesis that transient neurons in the hippocampus6,7 provide positional information for the targeting of these fibres. Here we report that ablation of Cajal–Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal–Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal–Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.

Date: 1997
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DOI: 10.1038/385070a0

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