Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway

Andrew M. Batchelor and John Garthwaite
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Andrew M. Batchelor: University College London
John Garthwaite: University College London

Nature, 1997, vol. 385, issue 6611, 74-77

Abstract: Abstract IN the classical view, a central neuron integrates incoming synaptic information by simple algebraic summation of the resultant bioelectrical signals that coincide in time. The voltage dependence of the NMDA (N-methyl-D-aspartate) type of iono-tropic glutamate receptor endows neurons with an additional tool that allows one synaptic input to influence another, providing, again, that the two are active simultaneously1. Here we identify a new mechanism by which non-coincident signals generated by different synaptic inputs are integrated. The device serves to regulate neuronal excitation through G-protein-coupled, metabotropic glutamate receptors (mGluRs)2 in a powerful and specific manner. We show that, in cerebellar Purkinje cells, a single activation of the climbing–fibre input markedly potentiatesmGluR-mediated excitation at parallel–fibre synapses3. The potentiation results from a transient rise in cytosolic Ca2+ which is 'memorized' in such a way that it promotes excitation through mGluRs for about two minutes. A Ca2+ -transient is also effective if imposed up to two seconds after parallel-fibre stimulation. By allowing temporally and spatially dispersed synaptic signals to be assimilated, this mechanism adds a new element to the computational power of central neurons.

Date: 1997
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DOI: 10.1038/385074a0

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