Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

Leandros Arvanitakis, Elizabeth Geras-Raaka, Anjali Varma, Marvin C. Gershengorn and Ethel Cesarman
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Leandros Arvanitakis: Cornell University Medical College
Elizabeth Geras-Raaka: Cornell University Medical College
Anjali Varma: Cornell University Medical College
Marvin C. Gershengorn: Cornell University Medical College
Ethel Cesarman: Cornell University Medical College

Nature, 1997, vol. 385, issue 6614, 347-350

Abstract: Abstract Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi's sarcoma1,2 and in primary-effusion (body-cavity-based) lymphomas3, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpes-virus with homology to herpesvirus Saimiri and Epstein-Barr virus1,4, both of which can transform lymphocytes5. Cloning of a KSHV genome fragment revealed the presence of an open reading frame encoding a putative G-protein-coupled receptor6 that is homologous to a G-protein-coupled receptor encoded by herpes-virus Saimiri7,8 and to human interleukin-8 receptors9,10. Here we show that the KSHV G-protein-coupled receptor is a bona fide signalling receptor which has constitutive (agonist-independent) activity in the phosphoinositide–inositoltrisphosphate–protein kinase C pathway. Furthermore, the KSHV G-protein-coupled receptor stimulates cellular proliferation, making it a candidate viral oncogene.

Date: 1997
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DOI: 10.1038/385347a0

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