The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors

Antoine Guichet, John W. R. Copeland, Miklós Erdélyi, Daniela Hlousek, Péter Závorszky, Jacqueline Ho, Susan Brown, Anthony Percival-Smith, Henry M. Krause and Anne Ephrussi
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Antoine Guichet: European Molecular Biology Laboratory
John W. R. Copeland: University of Toronto, Charles H. Best Institute
Miklós Erdélyi: European Molecular Biology Laboratory
Daniela Hlousek: University of Toronto, Charles H. Best Institute
Péter Závorszky: European Molecular Biology Laboratory
Jacqueline Ho: University of Western Ontario
Susan Brown: Kansas State University
Anthony Percival-Smith: University of Western Ontario
Henry M. Krause: University of Toronto, Charles H. Best Institute
Anne Ephrussi: European Molecular Biology Laboratory

Nature, 1997, vol. 385, issue 6616, 548-552

Abstract: Abstract Nuclear hormone receptors and homeodomain proteins are two classes of transcription factor that regulate major developmental processes. Both depend on interactions with other proteins for specificity and activity. The Drosophila gene fushi tarazu (ftz)y which encodes a homeodomain protein1 (Ftz), is required zygo-tically for the formation of alternate segments in the developing embryo2. Here we show that the orphan nuclear receptor α Ftz-Fl (ref. 3), which is deposited in the egg during oogenesis4, is an obligatory cofactor for Ftz. The two proteins interact specifically and directly, both in vitro and in vivo, through a conserved domain in the Ftz polypeptide. This interaction suggests that other nuclear receptor/homeodomain protein interactions maybe important and common in developing organisms.

Date: 1997
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DOI: 10.1038/385548a0

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