Crystal structure of the Src family tyrosine kinase Hck

Frank Sicheri, Ismail Moarefi and John Kuriyan
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Ismail Moarefi: The Rockefeller University
John Kuriyan: The Rockefeller University

Nature, 1997, vol. 385, issue 6617, 602-609

Abstract: Abstract The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 Å resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

Date: 1997
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DOI: 10.1038/385602a0

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