Regulation of telomere length and function by a Myb-domain protein in fission yeast

Julia Promisel Cooper, Elaine R. Nimmo, Robin C. Allshire and Thomas R. Cech
Additional contact information
Julia Promisel Cooper: University of Colorado
Elaine R. Nimmo: Western General Hospital
Robin C. Allshire: Western General Hospital
Thomas R. Cech: University of Colorado

Nature, 1997, vol. 385, issue 6618, 744-747

Abstract: Abstract Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic chromosomes1,2, are essential for complete replication3–5, and regulation of their length has been a focus of research on tumorigenesis6–8. In the budding yeast Saccharomyces cerevisiae, the protein Raplp binds to telomeric DNA and functions in the regulation of telomere length9–12. A human telomere protein, hTRF (human TTAGGG repeat factor) binds the telomere sequence in vitro13 and localizes to telomeres cytologically14, but its functions are not yet known. Here we use a genetic screen to identify a telomere protein in fission yeast, Tazlp (telomere-associated in Schizosaccharomyces pombe), that shares homology to the Myb proto-oncogene DNA-binding domain with hTRF. Disruption or deletion of the taz1+ gene causes a massive increase in telomere length. Tazlp is required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase1,3, or may protect against activation of telomerase-independent pathways of telomere elongation8.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/385744a0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:385:y:1997:i:6618:d:10.1038_385744a0

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/385744a0

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().