An endothelial receptor for oxidized low-density lipoprotein

Tatsuya Sawamura, Noriaki Kume, Takuma Aoyama, Hideaki Moriwaki, Hajime Hoshikawa, Yuichi Aiba, Takeshi Tanaka, Soichi Miwa, Yoshimoto Katsura, Toru Kita and Tomoh Masaki
Additional contact information
Tatsuya Sawamura: Kyoto University
Noriaki Kume: Kyoto University
Takuma Aoyama: Kyoto University
Hideaki Moriwaki: Kyoto University
Hajime Hoshikawa: Kyoto University
Yuichi Aiba: Kyoto University
Takeshi Tanaka: Japan Red Cross Saitama Branch
Soichi Miwa: Kyoto University
Yoshimoto Katsura: Kyoto University
Toru Kita: Kyoto University
Tomoh Masaki: Kyoto University

Nature, 1997, vol. 386, issue 6620, 73-77

Abstract: Abstract Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis1–4, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis5–7. Vascular endothelial cells in culture8,9 and in vivo10,11 internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors12–15. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.

Date: 1997
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DOI: 10.1038/386073a0

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