Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Klemens Kaupmann, Katharina Huggel, Jakob Heid, Peter J. Flor, Serge Bischoff, Stuart J. Mickel, Gary McMaster, Christof Angst, Helmut Bittiger, Wolfgang Froestl and Bernhard Bettler
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Klemens Kaupmann: Therapeutic Area Nervous System
Katharina Huggel: Therapeutic Area Nervous System
Jakob Heid: Therapeutic Area Nervous System
Peter J. Flor: Therapeutic Area Nervous System
Serge Bischoff: Therapeutic Area Nervous System
Stuart J. Mickel: Therapeutic Area Nervous System
Gary McMaster: Therapeutic Area Nervous System
Christof Angst: Therapeutic Area Nervous System
Helmut Bittiger: Therapeutic Area Nervous System
Wolfgang Froestl: Therapeutic Area Nervous System
Bernhard Bettler: Therapeutic Area Nervous System

Nature, 1997, vol. 386, issue 6622, 239-246

Abstract: Abstract GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

Date: 1997
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DOI: 10.1038/386239a0

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