Homer: a protein that selectively binds metabotropic glutamate receptors

P. R. Brakeman, A. A. Lanahan, Richard O'Brien, K. Roche, C. A. Barnes, R. L. Huganir and P. F. Worley
Additional contact information
P. R. Brakeman: Johns Hopkins University School of Medicine
A. A. Lanahan: Johns Hopkins University School of Medicine
Richard O'Brien: Johns Hopkins University School of Medicine
K. Roche: National Institutes of Health
C. A. Barnes: University of Arizona
R. L. Huganir: Johns Hopkins University School of Medicine
P. F. Worley: Johns Hopkins University School of Medicine

Nature, 1997, vol. 386, issue 6622, 284-288

Abstract: Abstract Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors1 and ion channels2. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. The Homer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.

Date: 1997
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DOI: 10.1038/386284a0

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