EconPapers    
Economics at your fingertips  
 

Homer: a protein that selectively binds metabotropic glutamate receptors

P. R. Brakeman, A. A. Lanahan, Richard O'Brien, K. Roche, C. A. Barnes, R. L. Huganir and P. F. Worley
Additional contact information
P. R. Brakeman: Johns Hopkins University School of Medicine
A. A. Lanahan: Johns Hopkins University School of Medicine
Richard O'Brien: Johns Hopkins University School of Medicine
K. Roche: National Institutes of Health
C. A. Barnes: University of Arizona
R. L. Huganir: Johns Hopkins University School of Medicine
P. F. Worley: Johns Hopkins University School of Medicine

Nature, 1997, vol. 386, issue 6622, 284-288

Abstract: Abstract Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors1 and ion channels2. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. The Homer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.

Date: 1997
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/386284a0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386284a0

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/386284a0

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().

 
Page updated 2025-03-19
Handle: RePEc:nat:nature:v:386:y:1997:i:6622:d:10.1038_386284a0