Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

Concepción Rodriguez-Esteban, John W. R. Schwabe, Jennifer De La Peña, Bryon Foys, Brian Eshelman and Juan Carlos Izpisúa Belmonte
Additional contact information
Concepción Rodriguez-Esteban: The Salk Institute
John W. R. Schwabe: The Salk Institute
Jennifer De La Peña: The Salk Institute
Bryon Foys: The Salk Institute
Brian Eshelman: The Salk Institute
Juan Carlos Izpisúa Belmonte: The Salk Institute

Nature, 1997, vol. 386, issue 6623, 360-366

Abstract: Abstract Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-I, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is a boundary between cells expressing and not expressing Radical fringe. Thus, as in Drosophila, Radical fringe positions the ridge at the dorsoventral limb boundary.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/386360a0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:386:y:1997:i:6623:d:10.1038_386360a0

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/386360a0

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().